EGF, epidermal growth factor, 1950

N. diseases: 774; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2673648
Disease: Hypomagnesemia 4, Renal
Hypomagnesemia 4, Renal 		0.600 Biomarker disease GENOMICS_ENGLAND Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. 17671655 2007
CUI: C2673648
Disease: Hypomagnesemia 4, Renal
Hypomagnesemia 4, Renal 		0.600 GeneticVariation disease UNIPROT Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. 17671655 2007
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis 		0.240 Therapeutic disease RGD Changes in hepatic cell junctions structure during experimental necrotizing enterocolitis: effect of EGF treatment. 19390485 2009
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis 		0.240 Therapeutic disease RGD Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth factor for prevention of experimental necrotizing enterocolitis. 18607263 2008
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.200 Biomarker disease RGD Twenty-four hours after folic acid induced acute renal injury, creatinine increased from 0.3 +/- 0.03 mg/dl in controls to 2.0 +/- 0.8 mg/dl in folic acid injured kidneys (n = 4, p < 0.03). mRNA for the EGF receptor was increased nearly sevenfold by 24 h, and mRNA for the receptor was increased as early as 1 h following folic acid treatment. 11340354 2001
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 Biomarker disease PSYGENET A study of the functional significance of epidermal growth factor in major depressive disorder. 22504456 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.320 Biomarker disease PSYGENET The cis-phase interaction between the SNPs within the EGF locus may contribute toward the etiology of MDD. 22504456 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.300 Biomarker disease PSYGENET Assessment of possible replication in 847 cases of European descent from a large independent sample, the Collaborative Study of the Genetics of Alcoholism, yielded replication for DKK2 but not EGF. 20332099 2010
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.300 Biomarker disease PSYGENET Acute pharmacological inhibition of the EGF receptor (EGFR) in adult animals altered acute ethanol sensitivity in both flies and mice and reduced ethanol consumption in a preclinical rat model of alcoholism. 19464045 2009
CUI: C0279607
Disease: Adult Hepatocellular Carcinoma
Adult Hepatocellular Carcinoma 		0.300 SusceptibilityMutation disease ORPHANET A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. 21440548 2011
CUI: C4510731
Disease: Familial primary hypomagnesemia with normocalciuria and normocalcemia
Familial primary hypomagnesemia with normocalciuria and normocalcemia 		0.300 GermlineCausalMutation disease ORPHANET Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. 17671655 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.150 Biomarker disease HPO
CUI: C0151723
Disease: Hypomagnesemia
Hypomagnesemia 		0.140 Biomarker phenotype HPO
CUI: C0018681
Disease: Headache
Headache 		0.100 Biomarker phenotype HPO
CUI: C0025958
Disease: Microcephaly
Microcephaly 		0.100 Biomarker disease HPO
CUI: C0026351
Disease: Moderate intellectual disability
Moderate intellectual disability 		0.100 Biomarker disease HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0042571
Disease: Vertigo
Vertigo 		0.100 Biomarker phenotype HPO
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.100 Biomarker disease HPO
CUI: C0746674
Disease: Generalized muscle weakness
Generalized muscle weakness 		0.100 Biomarker phenotype HPO
CUI: C0856975
Disease: Autistic behavior
Autistic behavior 		0.100 Biomarker disease HPO
CUI: C1531647
Disease: Cerebral ventriculomegaly
Cerebral ventriculomegaly 		0.100 Biomarker phenotype HPO
CUI: C1846176
Disease: Hyperactive deep tendon reflexes
Hyperactive deep tendon reflexes 		0.100 Biomarker phenotype HPO
CUI: C1848207
Disease: Poor speech
Poor speech 		0.100 Biomarker phenotype HPO
CUI: C1857704
Disease: Abnormal myelination
Abnormal myelination 		0.100 Biomarker phenotype HPO